In a recent issue of Nature, Barends et al. ¹ studied the photodissociation of carboxymyoglobin with ultrafast laser pump-probe serial femtosecond crystallography experiments. They observed significant differences in heme protein structural dynamics for biologically relevant 1-photon excitation relative to high excitation leading to the absorption of several photons per heme.

Links: https://doi.org/10.1016/j.str.2024.05.008